Ectopic Expression of the Neuropeptide Pigment-Dispersing Factor Alters Behavioral Rhythms inDrosophila melanogaster

Apr 25, 2000The Journal of neuroscience : the official journal of the Society for Neuroscience

Changing levels of a brain chemical affect daily activity patterns in fruit flies

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Abstract

Ectopic expression of the pigment-dispersing factor (PDF) in Drosophila resulted in severe alterations in activity rhythms in several experimental lines.

  • PDF acts as a neuromodulator in the dorsal central brain, influencing behavioral rhythms.
  • Only ectopic expression of pdf in specific neurons projecting to the dorsal central brain significantly affected activity rhythms.
  • Overexpression of pdf in pacemaker neurons or neurons expressing the clock genes period and timeless did not disrupt the activity rhythm.
  • Rhythmic accumulation of PDF was observed in central brain terminals of flies with normal pdf expression.
  • In neurons without the clock genes per and tim, PDF may be continuously processed, leading to constant secretion at nerve terminals.

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