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Neuropeptide F immunoreactive clock neurons modify evening locomotor activity and free‐running period in Drosophila melanogaster
Neuropeptide F–producing clock neurons influence evening movement and internal day length in fruit flies
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Abstract
The investigation identified five distinct subsets of neuropeptide F-positive clock neurons in Drosophila melanogaster.
- Specific subsets of clock neurons are linked to daily locomotor rhythms and differ in neurotransmitter composition.
- The fifth s-LN(v) and certain l-LN(v)s were newly identified as neuropeptide F-positive neurons.
- Ablation of NPF-expressing neurons affects the free-running period and evening activity amplitude in light-dark cycles.
- Simultaneous ablation of NPF and pigment dispersing factor neurons led to an earlier peak in evening activity and reduced amplitude.
- RNA interference targeting NPF alongside pigment dispersing factor suggests its role in regulating evening activity.
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