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Peptidergic clock neurons in Drosophila: Ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons
Peptide-producing clock neurons in fruit flies: two peptides in specific groups of side brain cells
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Abstract
About 150 clock neurons are clustered in different groups in the brain of Drosophila.
- Some clock neurons are identified as principal oscillators for morning and evening activity, with specific types responsible for each time period.
- Novel neuropeptides, ion transport peptide (ITP) and short neuropeptide F (sNPF), have been discovered in certain subpopulations of lateral neurons.
- ITP was found in one of the six dorsal lateral neurons (LN(d)s) that coexpresses long neuropeptide F and cryptochrome.
- sNPF was detected in two LN(d)s that also express cryptochrome, distinguishing them from other LN(d)s that express NPF.
- Five of the six LN(d)s have identified neuropeptides, highlighting anatomical and functional heterogeneity among these neurons.
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