Comparative Analysis of Pdf-Mediated Circadian Behaviors BetweenDrosophila melanogasterandD. virilis

Jan 21, 2009Genetics

Comparison of daily rhythm behaviors controlled by Pdf between two fruit fly species

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Abstract

Daily locomotor activity patterns of Drosophila virilis differ significantly from those of Drosophila melanogaster.

  • D. virilis adults exhibit primarily photophase activity under light:dark cycles, becoming arrhythmic or weakly rhythmic in constant conditions.
  • The activity patterns of D. virilis resemble those of the Pdf(01) mutant of D. melanogaster.
  • Endogenous expression of the pigment-dispersing factor (Pdf) neuropeptide is not detected in the s-LN(v)-like neurons of D. virilis adults.
  • The lack of DvPdf in the s-LN(v)-like neurons may contribute to the Pdf(01)-like behavioral traits observed in D. virilis.
  • Cis-regulatory elements of the DvPdf transgene can direct expression in all endogenous Pdf neurons, including s-LN(v)'s, in a D. melanogaster host.
  • Differences in Pdf transcription regulation between the two species are associated with the establishment of species-specific locomotor activity patterns.

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