The Role of the Dorsal Nucleus of the Lateral Lemniscus in Shaping the Auditory Response Properties of the Central Nucleus of the Inferior Collicular Neurons in the Albino Mouse

Aug 26, 2018Neuroscience

How a Hearing Brainstem Area Influences Sound Responses in the Midbrain of Albino Mice

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Abstract

Brief electrical stimulation of the contralateral dorsal nucleus of the lateral lemniscus may alter the auditory response properties of individual neurons in the inferior colliculus.

Electrical stimulation can increase or decrease the number of impulses generated by modulated inferior colliculus neurons.
Changes in response latency and discharge duration were observed following brief electrical stimulation.
A 30-minute period of electrical stimulation led to variations in the best frequency and minimum threshold of the neurons.
Recoveries of the varied response parameters occur differently among individual modulated neurons.

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In the ascending auditory pathway, the central nucleus of the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many bilateral lower auditory nuclei, intrinsic projections within the IC, contralateral IC through the commissure of the IC and from the auditory cortex. All these presynaptic excitatory and inhibitory inputs dynamically shape and modulate the auditory response properties of individual IC neurons. For this reason, acoustic response properties vary among individual IC neurons due to different activity pattern of presynaptic inputs. The present study examines modulation of auditory response properties of IC neurons by combining sound stimulation with focal electrical stimulation of the contralateral dorsal nucleus of the lateral lemniscus (referred to as ES) in the albino mouse. Brief ESproduces variation (increase or decrease) in the number of impulses, response latency and discharge duration of modulated IC neurons. Additionally, 30-minute short-term ESalone produces variation in the best frequency (BF) and minimum threshold (MT) of modulated IC neurons. These varied response parameters recover in different manner and time course among individual modulated IC neurons. Possible pathways and neural mechanisms underlying these findings are discussed. DNLL DNLL DNLL

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The Role of the Dorsal Nucleus of the Lateral Lemniscus in Shaping the Auditory Response Properties of the Central Nucleus of the Inferior Collicular Neurons in the Albino Mouse

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