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Drosophila Brahma complex remodels nucleosome organizations in multiple aspects
How the Brahma complex in fruit flies changes DNA packaging in different ways
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Abstract
Brm knockdown in Drosophila larvae results in a decrease in occupancy throughout the genome.
- Nucleosome occupancy changes were observed globally, with a bias towards decreased occupancy.
- Limited impacts on nucleosome position shifts were noted following Brm knockdown.
- Changes in nucleosome fuzziness, a measure of positioning variability, were also detected.
- Alterations in nucleosome dynamics were particularly enriched in promoter regions of genes.
- Five distinct patterns of nucleosome reorganization were identified around the 5' ends of genes following Brm knockdown.
- Changes in adjacent genes to Brahma-dependent remodeling regions are associated with developmental and morphological processes.
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Key numbers
872
Occupancy Change
Differentially expressed genes with >2-fold change after Brm knockdown.
89.6%
Shift
Percentage of total that shifted after Brm knockdown.
3758
Remodeling Regions Identified
Distinct remodeling regions enriched in promoter areas.