Drp1 controls muscle size and mitochondrial health through the Erk1/2-Nur77 signaling pathway

Drp1 loss appears to drive skeletal muscle atrophy through impaired mitochondrial respiration and reduced Erk1/2-Nur77 signaling.

This preclinical muscle model study tested acute skeletal-muscle Drp1 deletion, Drp1-Parkin dual deletion, and clenbuterol-mediated pathway rescue.

The therapeutic implication is limited to experimental models, and clenbuterol rescue does not establish clinical benefit in human muscle degeneration.