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Drug delivery strategies to enhance the permeability of the blood–brain barrier for treatment of glioma
Methods to improve drug passage through the brain's protective barrier for treating brain tumors
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Abstract
Innovative technologies are being explored to enhance the permeability of the (BBB) for drug delivery in glioma treatment.
- Gliomas are highly lethal brain cancers associated with poor prognosis and frequent recurrences.
- The blood-brain barrier limits the effectiveness of many drugs that are successful against other tumors.
- Improving drug absorption through the BBB may enhance treatment efficacy for gliomas.
- Technologies such as nanotechniques and hyperthermia techniques show promise in increasing BBB permeability.
- and may facilitate drug delivery into brain tissue.
- Cell-mediated delivery methods are also being considered to optimize drug distribution within the brain.
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Key numbers
4.5%
5-year survival rate
Percentage of patients with malignant glioma surviving five years post-diagnosis.
3×
Nanoparticle penetration speed
Glucose-coated gold nanoparticles penetrate the at a speed three times faster than non-brain endothelium.
202%
Increase in drug penetration
Focused ultrasound with microbubbles increased drug penetration in animal models.