Full text is available at the source.
Abstract
TVP significantly enhanced cerebral blood perfusion and exhibited superior brain accumulation compared to MC3-based LNPs.
- A dual-functional ionizable lipid was developed by combining a neurovascular regulatory motif with the chemotherapeutic agent temozolomide.
- TVP showed improved brain delivery and selective localization in glioma tissues.
- The platform demonstrated intrinsic anti-glioma activity while effectively delivering nucleic acids.
- Co-loading with therapeutic nucleic acids resulted in strong inhibition of glioma progression through combined targeting strategies.
- TVP maintained favorable biosafety in both healthy and glioma-bearing mice.
Simplified