Important role of damaged cell energy centers and their cleanup in autism spectrum disorders

Dysfunctional mitochondria and mitophagy are closely associated with the onset of autism spectrum disorders (ASDs).

• Mitochondria provide essential energy to neurons and regulate critical processes such as cell death and calcium balance.
• Neurons, given their high energy demands, are particularly susceptible to mitochondrial dysfunction and mitophagy issues.
• Mitophagy is a process that removes damaged mitochondria to maintain mitochondrial health in neurons.
• Dysregulated mitophagy may contribute to the pathology of autism spectrum disorders.

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