Effective Connectivity of Functionally Anticorrelated Networks Under Lysergic Acid Diethylamide

In a study of 25 healthy adults, inhibitory connectivity from the salience network to the default mode network shifted to excitatory following LSD administration.

• The peak effects of LSD are associated with changes in the balance of connectivity between brain networks.
• Inhibitory connectivity from the default mode network to the dorsal attention network decreased under LSD.
• These connectivity changes may indicate a reduction in the functional anticorrelation between brain networks.
• Such alterations could be linked to the experience of ego dissolution, where the boundaries between self and world blur.

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