Reduced ability to recall past events is linked to breakdown of the brain's default thinking network under LSD

LSD (75 μg) administration resulted in significantly fewer mental spaces for the past during spontaneous mentation.

• Healthy volunteers reported a decrease in mental references to the past while under the influence of LSD.
• The reduced references to the past were correlated with the overall intensity of LSD's subjective effects.
• No significant changes were noted in mental references to the present or future with LSD.
• Decreased connectivity within the default-mode network was associated with less mental time travel to the past.
• Findings may have implications for therapeutic use of LSD and psychedelics in treating conditions like depression.

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