Effectiveness and safety of repeated under-the-skin ketamine for hard-to-treat depression and how past ketamine use may affect results

Longer-term outcome and safety data of repeated subcutaneous racemic ketamine for treatment-resistant depression is lacking.

• The effects of prior ketamine treatment on subsequent response in treatment-resistant depression remain unclear.
• Limited data exists regarding the safety profile of repeated subcutaneous racemic ketamine administration.
• Further investigation is needed to understand the long-term outcomes associated with this treatment approach.

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