Endurance exercise effects on muscle and liver metabolism in male rats with different fitness during long-term body clock disruption

Circadian rhythm disruption is a major risk factor for metabolic dysfunction in skeletal muscle and liver.

• Endurance training is known to improve metabolic health.
• The timing of exercise may influence metabolic adaptations.
• The duration of training could affect outcomes in the context of circadian rhythm disruption.
• Effects of exercise timing and training duration on metabolism under circadian disruption remain unclear.

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