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Effects of Glucagon‐Like Peptide‐1 Receptor Agonists, Sodium‐Glucose Cotransporter‐2 Inhibitors, and Their Combination on Endothelial Glycocalyx, Arterial Function, and Myocardial Work Index in Patients With Type 2 Diabetes Mellitus After 12‐Month Treatment
Effects of Diabetes Drugs Alone and Combined on Blood Vessel Lining, Artery Health, and Heart Work in Type 2 Diabetes After One Year
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Abstract
After 12 months of treatment, all patients improved in multiple vascular and cardiac function markers.
- Patients treated with GLP-1 receptor agonists (GLP-1RA), sodium-glucose cotransporter-2 inhibitors (SGLT-2i), or their combination showed greater reductions in vascular markers compared to those treated with insulin.
- The combination therapy led to a 12.7% increase in global work index compared to insulin's 3.1%.
- SGLT-2i and the combination therapy resulted in a greater decrease in pulse wave velocity (PWV) than insulin, with reductions of 10.1% and 13% respectively.
- The dual therapy had the most significant impact on patients with a left ventricular ejection fraction below 55%.
- All treatment groups demonstrated improvements in perfused boundary region, PWV, and global strain metrics within the 12-month period.
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