Effects of Vasoactive Intestinal Peptide Genotype on Circadian Gene Expression in the Suprachiasmatic Nucleus and Peripheral Organs

Jun 2, 2011Journal of biological rhythms

How a gene for a blood flow and nerve signal protein affects daily rhythm genes in the brain’s clock and other body organs

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Abstract

Loss of the neuropeptide vasoactive intestinal polypeptide (VIP) leads to greatly attenuated rhythms in clock gene expression in the suprachiasmatic nucleus (SCN) of VIP-deficient mice.

  • VIP-deficient mice showed diminished circadian gene expression rhythms in the SCN compared to wild-type mice.
  • In the adrenal glands, the absence of VIP resulted in a loss of rhythmic expression for the Per1 gene.
  • The liver exhibited altered phase timing of diurnal gene expression rhythms in VIP-deficient mice.
  • Ex vivo studies indicated low amplitude rhythms in the SCN of VIP-deficient mice.
  • Absence of VIP altered the phase relationships between the SCN and peripheral oscillators.

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