The lancet. Diabetes & endocrinology

Effectiveness and safety of oral orforglipron in Japanese people with obesity

Updated

Abstract

Orforglipron has demonstrated bodyweight reduction and cardiometabolic benefits in adults with obesity.

  • Orforglipron is a small-molecule, non-peptide drug that activates GLP-1 receptors.
  • The drug has shown efficacy in reducing body weight in phase 3 trials.
  • Cardiometabolic benefits have been observed alongside weight reduction.
  • The study focuses on assessing orforglipron's effects specifically in Japanese adults with obesity.

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