Efficacy and safety of time-of-day infusion of pemetrexed plus platinum for patients with advanced non-small cell lung cancer: a retrospective cohort study

Journal of thoracic disease

Effectiveness and safety of giving pemetrexed plus platinum chemotherapy at different times of day for advanced lung cancer patients

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Abstract

Essence

Morning pemetrexed-plus-platinum infusion was linked to longer progression-free survival in advanced NSCLC.

Evidence

This retrospective single-center cohort analyzed 132 advanced NSCLC patients treated from 2018 to 2023, comparing morning infusion before 2:00 PM (n=58) with afternoon infusion (n=74).

Caveat

The nonrandomized design limits causal inference, and the abstract's PFS and adverse-event reporting is partly malformed despite noting similar overall TEAE rates.

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Full Text

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