Knockdown of eIF3a attenuates the pro-fibrogenic response of hepatic stellate cells induced by TGF-β1.
Reducing eIF3a lowers liver scar cell activation caused by TGF-β1
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Abstract
The expression of eIF3a was up-regulated in human liver fibrotic tissues and activated hepatic stellate cells (HSCs).
- Knockdown of eIF3a suppressed TGF-β-induced HSC proliferation and the expression of α-smooth muscle actin (α-SMA) and collagen I.
- Inhibition of eIF3a also reduced the expression of p-Smad3 induced by TGF-β1 in HSCs.
- These findings suggest eIF3a may regulate HSC activation, potentially through the TGF-β1/Smad3 signaling pathway.
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