Knockdown of elF3a inhibits collagen synthesis in renal fibroblasts via Inhibition of transforming growth factor-β1/Smad signaling pathway.
Reducing elF3a lowers collagen production in kidney fibroblasts by blocking the TGF-β1/Smad signaling pathway
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Abstract
eIF3a was up-regulated in renal fibrotic tissues and cells treated with TGF-β1.
- The role of eIF3a in renal fibrosis is not fully understood.
- Knockdown of eIF3a significantly reduced TGF-β1-induced expression of α-smooth muscle actin and collagen I.
- Knockdown of eIF3a also decreased activation of Smad3 in TGF-β1-treated cells.
- Inhibition of eIF3a may disrupt collagen synthesis in renal fibroblasts through the TGF-β1/Smad signaling pathway.
- eIF3a could be considered a potential target for treating renal fibrosis.
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