Full text is available at the source.
Inhibitory effect of l-mimosine on bleomycin-induced pulmonary fibrosis in rats: Role of eIF3a and p27
l-Mimosine may reduce lung scarring caused by bleomycin in rats through effects on cell growth regulators eIF3a and p27
AI simplified
Abstract
L-mimosine treatment significantly ameliorated bleomycin-induced pulmonary fibrosis in rats.
- Decreased expression of eukaryotic translation initiation factor 3a (eIF3a) is associated with cell cycle arrest.
- L-mimosine treatment reversed the up-regulation of eIF3a, α-SMA, collagen I, and collagen III caused by bleomycin.
- L-mimosine treatment also increased p27 expression, which was down-regulated by bleomycin.
- In vitro, L-mimosine reduced the proliferation of pulmonary fibroblasts and the expression of fibrosis markers induced by TGF-β1.
- Knockdown of eIF3a gene expression reversed TGF-β1-induced effects on fibroblast proliferation and fibrosis-related protein expressions.
AI simplified