Einstein-Nathan Shock Center: translating the hallmarks of aging to extend human health span

Aug 31, 2021GeroScience

Using Key Aging Signs to Help People Stay Healthy Longer

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Longevity & Aging on OpenScience ↗PubMed ↗DOI ↗

Abstract

The Einstein-Nathan Shock Center (E-NSC) integrates research across 6 out of 7 pillars of aging to advance drug discovery in geroscience.

E-NSC conducts NIH-supported research programs focusing on key hallmarks of aging such as metabolism, genetic factors, and stem cell regeneration.
The center provides unique research support cores that enhance collaboration and innovation among scientists.
Data from genomics, proteomics, and metabolomics are utilized to study human longevity and inform aging-targeting drug development.
Access to biological samples from elderly subjects in clinical trials supports advancements in translational biological research.

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The overarching mission of the Einstein-Nathan Shock Center (E-NSC) is to make scientific discoveries in geroscience, leveraging on the expertise in our center in 6 out of the 7 pillars of aging, and to translate their effects towards drug discovery. The relevance of this basic biology of aging discoveries to humans will be confirmed through the unique gero-human resource at E-NSC. This is achieved through services provided by E-NSC, connectivity among its members, attracting worldwide investigators, and providing them with the opportunities to become future leaders. The two central components of the E-NSC are (a) cutting-edge research programs and (b) unique E-NSC research support cores. E-NSC scientists lead NIH-supported cutting-edge research programs that integrate key hallmarks of aging including proteostasis/autophagy, metabolism/inflammaging, genetic/epigenetics, stem cells/regeneration, and translational aging/longevity. Since the inception of the E-NSC, the well-integrated, collaborative, and innovative nature of the multiple supporting state-of-the-art E-NSC research cores form the bedrock of research success at the E-NSC. The three state-of-the-art E-NSC research cores, (i) Proteostasis of Aging Core (PAC), (ii) the Health Span Core (HSC), and (iii) the Human Multi-Omics Core (HMOC), have allowed impressive expansion of translational biological research programs. Expansion was facilitated through the wealth of data coming from genomics/proteomics and metabolomic analysis on human longevity studies, due to access to a variety of biological samples from elderly subjects in clinical trials with aging-targeting drugs, and new drug design services via the PAC to target the hallmarks of aging.

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Einstein-Nathan Shock Center: translating the hallmarks of aging to extend human health span

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