Oklahoma Nathan Shock Aging Center — assessing the basic biology of aging from genetics to protein and function

Oct 4, 2021GeroScience

Oklahoma Nathan Shock Aging Center – studying the basic biology of aging from genes to proteins and body functions

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Abstract

The Oklahoma Nathan Shock Center offers unique services across four research cores to support aging research.

The Multiplexing Protein Analysis Core can measure the levels, synthesis, and turnover of hundreds of proteins related to aging pathways.
The Genomic Sciences Core enables studies on how age and anti-aging interventions affect DNA methylation, mitochondrial genome variations, and single-cell transcriptomes.
The Geroscience Redox Biology Core provides assessments of oxidative stress and mitochondrial function, which are linked to aging and age-related diseases.
The GeroInformatics Core assists with data analysis and offers specialized software for interpreting aging-related research results.
The Geropathology Research Resource allows for pathological assessments of mice using the Geropathology Grading Platform.

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The Oklahoma Shock Nathan Shock Center is designed to deliver unique, innovative services that are not currently available at most institutions. The focus of the Center is on geroscience and the development of careers of young investigators. Pilot grants are provided through the Research Development Core to junior investigators studying aging/geroscience throughout the USA. However, the services of our Center are available to the entire research community studying aging and geroscience. The Oklahoma Nathan Shock Center provides researchers with unique services through four research cores. The Multiplexing Protein Analysis Core uses the latest mass spectrometry technology to simultaneously measure the levels, synthesis, and turnover of hundreds of proteins associated with pathways of importance to aging, e.g., metabolism, antioxidant defense system, proteostasis, and mitochondria function. The Genomic Sciences Core uses novel next-generation sequencing that allows investigators to study the effect of age, or anti-aging manipulations, on DNA methylation, mitochondrial genome heteroplasmy, and the transcriptome of single cells. The Geroscience Redox Biology Core provides investigators with a comprehensive state-of-the-art assessment of the oxidative stress status of a cell, e.g., measures of oxidative damage and redox couples, which are important in aging as well as many major age-related diseases as well as assays of mitochondrial function. The GeroInformatics Core provides investigators assistance with data analysis, which includes both statistical support as well as analysis of large datasets. The Core also has developed number of unique software packages to help with interpretation of results and discovery of new leads relevant to aging. In addition, the Geropathology Research Resource in the Program Enhancement Core provides investigators with pathological assessments of mice using the recently developed Geropathology Grading Platform.

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Oklahoma Nathan Shock Aging Center — assessing the basic biology of aging from genetics to protein and function

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