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Electroacupuncture Improves Learning and Memory Abilities via Activating AMPK/mTOR-Induced Autophagy in APP/PS1 Mice
Electroacupuncture may improve learning and memory by triggering cell cleanup processes in a mouse model of Alzheimer's disease
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Abstract
Electroacupuncture treatment improved cognitive function in APP/PS1 transgenic mice with Alzheimer's disease.
- APP/PS1 mice showed significant impairments in spatial learning and memory.
- Electroacupuncture treatment reduced amyloid-beta deposition in the hippocampus.
- Neuronal apoptosis in the hippocampal tissues was alleviated following electroacupuncture.
- Electroacupuncture promoted autophagy and activated the AMPK/mTOR signaling pathway in the hippocampus.
- These findings suggest that electroacupuncture may improve cognitive deficits through enhanced amyloid clearance and reduced neuronal death.
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