Beyond C, H, O, and N! Analysis of the Elemental Composition of U.S. FDA Approved Drug Architectures

Sep 26, 2014Journal of medicinal chemistry

Analysis of the Element Elements Found in FDA-Approved Drug Structures Beyond Carbon, Hydrogen, Oxygen, and Nitrogen

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Abstract

Sulfur, chlorine, fluorine, and phosphorus constitute about 90% of elemental substitutions in FDA approved pharmaceuticals.

Sulfur is the fifth most commonly used element in pharmaceuticals, followed by chlorine, fluorine, and phosphorus.
The remaining 10% of elemental substitutions involve 16 other elements, with bromine, iodine, and iron being the most prevalent.
A detailed analysis of chlorinated drugs was conducted, examining factors such as approval date and disease condition.
A new poster was created to illustrate the structures of chlorinated pharmaceuticals to support the analysis.
Phosphorus, bromine, and iodine-containing drugs were also closely analyzed in the study.

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The diversity of elements among U.S. Food and Drug Administration (FDA) approved pharmaceuticals is analyzed and reported, with a focus on atoms other than carbon, hydrogen, oxygen, and nitrogen. Our analysis reveals that sulfur, chlorine, fluorine, and phosphorous represent about 90% of elemental substitutions, with sulfur being the fifth most used element followed closely by chlorine, then fluorine and finally phosphorous in the eighth place. The remaining 10% of substitutions are represented by 16 other elements of which bromine, iodine, and iron occur most frequently. The most detailed parts of our analysis are focused on chlorinated drugs as a function of approval date, disease condition, chlorine attachment, and structure. To better aid our chlorine drug analyses, a new poster showcasing the structures of chlorinated pharmaceuticals was created specifically for this study. Phosphorus, bromine, and iodine containing drugs are analyzed closely as well, followed by a discussion about other elements.

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Beyond C, H, O, and N! Analysis of the Elemental Composition of U.S. FDA Approved Drug Architectures

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