Elevated Serum Trimethylamine N-Oxide Levels Are Associated with Mortality in Male Patients on Peritoneal Dialysis

The median serum TMAO level was 34.5 μM in 1,032 patients treated with peritoneal dialysis.

• 24% of patients died during a median follow-up of 63.7 months.
• Elevated serum TMAO levels were associated with an increased risk of all-cause mortality (adjusted SHR, 1.22).
• The association between elevated TMAO levels and all-cause mortality was statistically significant (p = 0.039).
• In men, higher serum TMAO levels were linked to an increased risk of both all-cause (SHR, 1.37) and CV mortality (SHR, 1.41).
• No significant association was found between TMAO levels and mortality in female patients.

AI simplified