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Abstract
Recent advances in understanding the blood-brain barrier (BBB) have led to strategies that may enhance drug delivery to brain metastases.
- The blood-brain barrier and brain-tumour barrier present significant challenges for treating brain metastasis due to their restrictive nature.
- Innovative strategies have been developed to improve permeability of the BBB and BTB, potentially allowing more effective drug delivery.
- Novel agents, including targeted therapies and immunotherapies, have shown promising intracranial activity against brain metastasis in preclinical and clinical studies.
- The review emphasizes the importance of understanding the biological properties of the BBB/BTB for advancing therapeutic approaches.
- Considerations for accelerating the clinical translation of new drugs for brain metastasis are discussed.
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