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Abstract
Recent advancements in therapies targeting the Blood-Brain Barrier (BBB) offer new strategies for treating brain tumors.
- Convection-Enhanced Delivery (CED) and RNA-based therapeutics may enhance drug delivery directly to tumor sites while reducing systemic toxicity.
- Theranostic nanoparticles and CRISPR-Cas9 gene editing could provide real-time monitoring and precision-targeted therapy for brain cancer.
- Techniques like magnetic nanoparticles, intranasal drug administration, and focused ultrasound with microbubbles are being refined to improve drug penetration across the BBB.
- Peptide-based delivery systems and small molecules that mimic natural transport pathways may accelerate the discovery of more effective brain cancer therapies.
- Combination therapies that integrate BBB-penetrant drugs with conventional treatments are being explored to potentially enhance treatment efficacy.
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