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Abstract
Innovative strategies are being developed to enhance drug penetration across the blood-brain barrier in glioblastoma multiforme (GBM) treatment.
- GBM is characterized by rapid growth, resistance to therapies, and features like hypoxia and chemoresistance.
- The blood-brain barrier and tumor microenvironment significantly influence treatment outcomes.
- Innovative therapies include monoclonal antibodies, small-molecule inhibitors, and novel drug delivery systems.
- Immunotherapy approaches, such as immune checkpoint inhibitors and vaccines, may improve patient prognosis.
- Recent clinical trials and preclinical studies provide insights into the current and future landscape of GBM treatment.
- Personalized medicine approaches aim to tailor therapies based on individual patient profiles for improved efficacy.
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