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Promising Approaches to Circumvent the Blood–Brain Barrier: Progress, Pitfalls and Clinical Prospects in Brain Cancer
New methods to bypass the brain's protective barrier: progress, challenges, and future chances in treating brain cancer
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Abstract
Biochemical modifications and local delivery methods may enhance drug transport across the blood-brain barrier (BBB) for central nervous system diseases.
- Methods such as focused ultrasound and microbubbles could disrupt the BBB to facilitate drug delivery.
- Targeting receptors that allow transport across the BBB may enable noninvasive delivery of both small molecule and biological cancer therapies.
- Local delivery techniques could allow for high doses while minimizing systemic exposure.
- Clinical trials indicate potential for these innovative approaches but highlight ongoing challenges in CNS drug development.
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