Emerging Roles of Modern Lifestyle Factors in Microbiome Stability and Functionality

📖 Top 50% JournalJan 26, 2026Current clinical microbiology reports

How Modern Lifestyle Habits Affect Gut Microbiome Balance and Function

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗OA ↗

Abstract

Modern lifestyle factors may disrupt gut microbiota composition, contributing to health issues.

Circadian rhythm disruption, sleep deprivation, exercise, and stress are linked to changes in the gut bacterial community.
Alterations in the gut bacteriome could lead to dysregulation of host metabolism.
These changes in microbiota composition are associated with increased risks of inflammatory diseases and cancer.
The gut microbiome is relatively stable after age 3 but is influenced by diet, environment, and lifestyle.

AI simplified

PURPOSE OF REVIEW: It is now evident that the microorganisms living on and inside the human body modulate a myriad of host responses and activities. Particularly, the intestinal microbiota, which comprises diverse bacteria, fungi, archaea, viruses, and eukaryotic entities, forms a close relationship with the host. This relationship is essential for optimal biological function such as maintaining proper immune homeostasis, host metabolism, and prevention of pathogens colonization. The human gut microbiome is relatively stable after 3 years of age but is subjected to influences from diet, environment and lifestyle factors. This review covers recent findings on how lifestyle factors associated with modern society might affect the microbiome.

RECENT FINDINGS: Modern lifestyle factors including circadian rhythm disruption, sleep deprivation, exercise and stress impact the gut bacterial community (bacteriome) composition and function. The resultant gut bacteriome changes contribute to host metabolism dysregulation, inflammatory diseases and cancer development associated with these lifestyle factors.

SUMMARY: Lifestyle factors influence the gut bacteriome to modulate host health and disease risks. Understanding the mechanistic roles of diverse host-associated microorganisms played in lifestyle factors-associated disease risks holds the promise for developing novel approaches to alleviate the detrimental effects.

Key numbers

31%

CRC Risk Reduction with Healthy Sleep

Risk reduction among individuals with healthy sleep and lifestyle habits.

12%

CRC Risk Increase with Sleep Disorders

Increased risk associated with insomnia or irregular sleep patterns.

Full Text

We can’t show the full text here under this license. Use the link below to read it at the source.

View full text (PDF) ↗View full text (HTML) ↗View full text (PDF) ↗

Abstract

Key numbers

Full Text

Related papers