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Gut microbiota circadian rhythms: a key regulator of immunometabolic homeostasis
Daily rhythms of gut bacteria as important regulators of immune and metabolic balance
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Abstract
Disruptions in circadian crosstalk between the gut microbiota and the host may contribute to metabolic disorders.
- Host circadian clocks regulate microbial activity through feeding and sleep patterns.
- Microbial community composition and metabolic activity exhibit robust 24-hour oscillations under normal conditions.
- Loss of microbial rhythms is associated with impaired intestinal barrier function and chronic inflammation.
- Erratic eating patterns and shift work disrupt the temporal dialogue between the host and gut microbiota.
- Circadian crosstalk is linked to immune modulation and metabolic regulation in the host.
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