Cross-species physiological interactions of endocrine disrupting chemicals with the circadian clock

Nov 9, 2020General and comparative endocrinology

How hormone-disrupting chemicals affect the body’s internal clock across different species

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Endocrine disrupting chemicals (EDCs) dysregulated core clock and circadian rhythm network gene expression across species.

EDCs are associated with disruptions in reproductive, behavioral, and metabolic rhythms.
Circadian impacts from EDC exposure occur alongside endocrine and metabolic changes.
Impaired fertility and dysregulated metabolic and energetic homeostasis were observed following EDC exposure.
Extensive interactions between circadian and endocrine systems may influence physiological responses to EDCs.
The extent of circadian clock perturbation due to EDCs is not fully characterized.

AI simplified

Endocrine disrupting chemicals (EDCs) are endocrine-active chemical pollutants that disrupt reproductive, neuroendocrine, cardiovascular and metabolic health across species. The circadian clock is a transcriptional oscillator responsible for entraining 24-hour rhythms of physiology, behavior and metabolism. Extensive bidirectional cross talk exists between circadian and endocrine systems and circadian rhythmicity is present at all levels of endocrine control, from synthesis and release of hormones, to sensitivity of target tissues to hormone action. In mammals, a range of hormones directly alter clock gene expression and circadian physiology via nuclear receptor (NR) binding and subsequent genomic action, modulating physiological processes such as nutrient and energy metabolism, stress response, reproductive physiology and circadian behavioral rhythms. The potential for EDCs to perturb circadian clocks or circadian-driven physiology is not well characterized. For this reason, we explore evidence for parallel endocrine and circadian disruption following EDC exposure across species. In the reviewed studies, EDCs dysregulated core clock and circadian rhythm network gene expression in brain and peripheral organs, and altered circadian reproductive, behavioral and metabolic rhythms. Circadian impacts occurred in parallel to endocrine and metabolic alterations such as impaired fertility and dysregulated metabolic and energetic homeostasis. Further research is warranted to understand the nature of interaction between circadian and endocrine systems in mediating physiological effects of EDC exposure at environmental levels.

Full Text

Full text is available at the source.

View full text (XML) ↗View full text ↗

Cross-species physiological interactions of endocrine disrupting chemicals with the circadian clock

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief