DEC1/STRA13/SHARP2 and DEC2/SHARP1 Coordinate Physiological Processes, Including Circadian Rhythms in Response to Environmental Stimuli

DEC1 and DEC2 proteins are associated with regulating circadian rhythms and responding to environmental stimuli.

• DEC1 and DEC2 are clock proteins that are induced by the CLOCK:BMAL1 complex and suppress their own expression in a negative feedback loop.
• DEC1 responds to light and can adjust the central circadian clock's phase, while its upregulation by TGF-β influences the phase of peripheral clocks in tissues.
• Both DEC1 and DEC2 modulate signals that control circadian rhythms in behavior and metabolism.
• DEC1 and DEC2 are involved in responses to low oxygen levels, immune reactions, and cancer development.
• Their functions are mediated by direct binding to specific DNA elements or interactions with other transcription factors.
• Various factors, including growth factors and DNA-damaging agents, can induce DEC1 and/or DEC2 in a tissue-specific manner.

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