Tissue-Specific Disruption of Rhythmic Expression of Dec1 and Dec2 in Clock Mutant Mice

Clock mutation led to an extreme reduction of Dec1 expression in kidney, heart, and skeletal muscle.

• DEC1 and DEC2 transcription factors exhibit daily fluctuations in expression that influence the mammalian circadian rhythm.
• The Clock mutation significantly reduced Dec1 expression in kidney, heart, and skeletal muscle, but not in liver.
• Dec2 expression was strongly repressed in liver, kidney, and heart due to the Clock mutation, while it remained rhythmic in skeletal muscle.
• Per2 expression was also disrupted in a tissue-dependent manner by the Clock mutation, affecting its rhythmicity.
• The rhythmic expression of Dbp disappeared in all examined tissues of Clock mutant mice.
• Npas2 maintained significant rhythmic expression in liver and kidney, which was also influenced by the Clock mutation.

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