Disrupted daily patterns of Dec1 and Dec2 gene activity in different tissues of clock mutant mice

Clock mutation led to an extreme reduction of Dec1 expression in kidney, heart, and skeletal muscle.

• DEC1 and DEC2 transcription factors exhibit daily fluctuations in expression that influence the mammalian circadian rhythm.
• The Clock mutation significantly reduced Dec1 expression in kidney, heart, and skeletal muscle, but not in liver.
• Dec2 expression was strongly repressed in liver, kidney, and heart due to the Clock mutation, while it remained rhythmic in skeletal muscle.
• Per2 expression was also disrupted in a tissue-dependent manner by the Clock mutation, affecting its rhythmicity.
• The rhythmic expression of Dbp disappeared in all examined tissues of Clock mutant mice.
• Npas2 maintained significant rhythmic expression in liver and kidney, which was also influenced by the Clock mutation.

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