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Hormone-like FGFs and their brain signals linked to energy balance
Updated
Abstract
Endocrine fibroblast growth factors (FGFs) are crucial regulators of metabolism during energy availability fluctuations.
- FGF19, FGF21, and FGF23 are a unique subfamily of FGFs that act as hormones.
- These endocrine FGFs are involved in regulating lipid, glucose, and energy metabolism.
- FGF19 and FGF21 are associated with body weight loss and improved glucose control in both rodents and humans.
- In contrast, increased levels of FGF23 have been linked to insulin resistance and obesity.
- Emerging concepts suggest that endocrine FGF signaling in the brain may offer new therapeutic targets for metabolic disorders.
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