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Endogenous Circadian Clock Machinery in Cortical NG2-Glia Regulates Cellular Proliferation
Internal Biological Clock in Brain Support Cells Controls Their Growth
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Abstract
Murine express circadian clock genes rhythmically over a 24-hour period.
- The largest population of proliferative cells in the mature central nervous system is NG2-glia.
- NG2-glia proliferation peaks at times when circadian clock gene expression is highest.
- Conditional knockout of the clock component reduces both the density of cortical NG2-glia and their proliferation.
- In a model of neurotrauma, increased NG2-glia proliferation depends on the expression of circadian clock genes.
- Circadian rhythm disturbances are commonly associated with neurologic disorders, including traumatic brain injury.
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Key numbers
267.5 cells/mm vs 235.9 cells/mm
Decrease in Density
Comparison of total density in CKO vs. control mice at CT 0000.
17.1 cells/mm vs 8.4 cells/mm
Decrease in Proliferative
Comparison of proliferative density in CKO vs. control mice at CT 1200.