Journal of pineal research

Natural body clock control and daily timing changes of key metabolic health markers

Updated

Abstract

Endogenous circadian rhythms in cholesterol and other metabolic biomarkers were observed in a study involving 41 participants.

  • Circadian rhythms in cholesterol, HDL, LDL, albumin, total protein, VLDL, and triglycerides were identified under constant routine conditions.
  • These rhythms were largely obscured under typical daily conditions, with the exception of cholesterol, which maintained similar phases in both settings.
  • Simulated shiftwork resulted in a significant delay of the cholesterol rhythm by approximately -3.7 to -4.2 hours and a notable advance by +5.1 hours in abrupt shift protocols.
  • Dim Light Melatonin Onset (DLMO) also showed similar phase shifts during shiftwork simulations, with changes of -6.6 hours and +3.1 hours depending on the protocol.
  • Exploratory analysis indicated that metabolic biomarkers may experience phase shifts due to the effects of simulated shiftwork.

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Funding

Competing interests

Declaration of interests : LKG has nothing to declare. MSH has no conflicts of interest relative to the scientific content of this manuscript. In the spirit of open disclosure, however, she reports having provided limited paid consulting to The MathWorks, Inc., has received travel support/honoraria from the American Academy of Neurology and the Providence Sleep Research Interest Group, and has received payment from the Fonds de la Recherche Scientifique for a grant review. GCB has no conflicts of interest relative to the scientific content of this manuscript. In the spirit of open disclosure, however, he reports having US Patents related to the photoreceptor system for melatonin regulation (published/granted USPTO 15/089229, 15/085,522, 16/252,330, and 09/853428) and (pending USPTO 16,283652, and 16/657927). That intellectual property has been licensed by an independent company. He currently serves an expert witness for McCullough Hill Leary, PS. In addition, he and his research program have received financial, material and travel support from a range of federal, industrial and philanthropic organizations in the past and present. CAC reports grants from Cephalon Inc., Jazz Pharmaceuticals Plc., Inc., National Football League Charities, Optum, Philips Respironics, Inc., Regeneron Pharmaceuticals, ResMed Foundation, San Francisco Bar Pilots, Sanofi S.A., Sanofi-Aventis, Inc, Schneider Inc., Sepracor, Inc, Mary Ann & Stanley Snider via Combined Jewish Philanthropies, Sysco, Takeda Pharmaceuticals, Teva Pharmaceuticals Industries, Ltd., and Wake Up Narcolepsy; and personal fees from Bose Corporation, Boston Celtics, Boston Red Sox, Cephalon, Inc., Columbia River Bar Pilots, Ganésco Inc., Institute of Digital Media and Child Development, Klarman Family Foundation, Samsung Electronics, Quest Diagnostics, Inc., Teva Pharma Australia, Vanda Pharmaceuticals, Washington State Board of Pilotage Commissioners, Zurich Insurance Company, Ltd. In addition, CAC holds a number of process patents in the field of sleep/circadian rhythms (e.g., photic resetting of the human circadian pacemaker) and holds an equity interest in Vanda Pharmaceuticals, Inc. Since 1985, CAC has also served as an expert on various legal and technical cases related to sleep and/or circadian rhythms, including those involving the following commercial entities: Casper Sleep Inc., Comair/Delta Airlines, Complete General Construction Company, FedEx, Greyhound, HG Energy LLC, Purdue Pharma, LP, South Carolina Central Railroad Co., Steel Warehouse Inc., Stric-Lan Companies LLC, Texas Premier Resource LLC, and United Parcel Service (UPS). CAC receives royalties from the New England Journal of Medicine; McGraw Hill; Houghton Mifflin Harcourt/Penguin; and Philips Respironics, Inc. for the Actiwatch-2 and Actiwatch-Spectrum devices. CAC’s interests were reviewed and managed by Brigham and Women’s Hospital and Partners HealthCare in accordance with their conflict of interest policies. SWL reports commercial interests from the last 3 years (2018–2020). His interests were reviewed and managed by Brigham and Women’s Hospital and Partners HealthCare in accordance with their conflict of interest policies. No interests are directly related to the research or topic reported in this paper but, in the interests of full disclosure, are outlined below. SWL has received consulting fees from the BHP Billiton, EyeJust Inc., Noble Insights, Rec Room, Six Senses, Stantec and Team C Racing; and has current consulting contracts with Akili Interactive; Apex 2100 Ltd.; Consumer Sleep Solutions; Headwaters Inc.; Hintsa Performance AG; KBR Wyle Services, Light Cognitive; Lighting Science Group Corporation/HealthE; Mental Workout/Timeshifter and View Inc. He has received honoraria and travel or accommodation expenses from Emory University, Estée Lauder, Ineos, MIT, Roxbury Latin School, and University of Toronto, and travel or accommodation expenses (no honoraria) from IES, Mental Workout, Solemma, and Wiley; and royalties from Oxford University Press. He holds equity in iSleep pty. He has received an unrestricted equipment gift from F. Lux Software LLC, a fellowship gift from Stockgrand Ltd and holds an investigator-initiated grant from F. Lux Software LLC and a Clinical Research Support Agreement with Vanda Pharmaceuticals Inc. He is an unpaid Board Member of the Midwest Lighting Institute (non-profit). He was a Program Leader for the CRC for Alertness, Safety and Productivity, Australia, through an adjunct professor position at Monash University (2015–2019). He has served as a paid expert in legal proceedings related to light, sleep and health. SAR owns equity in Melcort Inc. SAR has provided paid consulting services to Sultan & Knight Limited, Bambu Vault LLC. SAR has received honoraria as an invited speaker and travel funds from Starry Skies Lake Superior, University of Minnesota Medical School, PennWell Corp., Seoul Semiconductor Co. LTD.
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