We can’t show the full text here under this license. Use the link below to read it at the source.
Engineered internal architecture of core-shell lipid nanoparticles promotes efficient mRNA endosomal release
Designed inner structure of lipid nanoparticles helps mRNA escape from cell compartments
AI simplified
Abstract
Au-LNPs achieve a twofold increase in endosomal escape and ~100-fold greater cytoplasmic mRNA diffusion compared to conventional lipid nanoparticles.
- Engineering LNPs with ionizable lipid-coated gold nanoparticles creates a more efficient internal structure.
- This new architecture stabilizes the particles at physiological pH and enhances their performance in acidic environments.
- Au-LNPs show improved mRNA expression in vitro and increase protein production in vivo by up to sevenfold.
- These particles also enhance immune responses to SARS-CoV-2 vaccines and improve treatment outcomes in triple-negative breast cancer models.
AI simplified
Key numbers
2×
Increase in Endosomal Escape Efficiency
Au-LNPs compared to conventional LNPs
~100-fold
Cytoplasmic mRNA Diffusion Enhancement
Au-LNPs compared to conventional LNPs
2×
Increase in Antibody Titers
Au-LNPs vs. conventional LNPs after initial immunization