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Abstract
Essence
A gold-core, core-shell lipid nanoparticle design improved mRNA endosomal escape and boosted downstream expression and therapeutic performance versus conventional LNPs.
Evidence
A nanoparticle platform study compared ionizable lipid-coated gold core-shell LNPs with conventional LNPs and found twofold higher endosomal escape, about 100-fold greater cytoplasmic mRNA diffusion, up to sevenfold higher in vivo protein production, stronger SARS-CoV-2 vaccine antibody responses, and better efficacy in a triple-negative breast cancer model.
Caveat
This is platform and preclinical evidence spanning in vitro and animal models, so it does not yet establish safety or efficacy in humans.
Simplified
mRNA Technology