Engineered extracellular vesicles and their mimics in cardiovascular diseases

May 4, 2022Journal of controlled release : official journal of the Controlled Release Society

Designed cell particles and similar tools in heart and blood vessel diseases

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Abstract

Extracellular vesicles (EVs) may provide new therapeutic options for cardiovascular diseases (CVDs) due to their superior properties.

  • CVDs are the leading cause of death globally.
  • Current treatments for CVDs face challenges such as low bioavailability and drug resistance.
  • EVs are lipid vesicles secreted by cells that are involved in the pathology of CVDs.
  • Engineered EVs and EV mimics could address the limitations of traditional pharmacological interventions.
  • The review discusses engineering strategies and potential applications of these engineered EVs and EV mimics in treating CVDs.

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