Enhanced healing of burn wounds by multifunctional alginate-chitosan hydrogel enclosing silymarin and zinc ‎oxide ‎nanoparticles

Aug 24, 2024Burns : journal of the International Society for Burn Injuries

Improved burn wound healing using a gel containing silymarin and zinc oxide nanoparticles

AI simplified

Regenerative Health on OpenScience ↗PubMed ↗DOI ↗

Abstract

The multifunctional hydrogel dressing led to nearly complete wound closure by day 21 in a rat model of full-thickness dermal burn wounds.

Zinc oxide nanoparticles were synthesized using phytochemicals from Elettaria cardamomum seeds extract.
The hydrogel displayed characteristics such as great water absorption, high porosity, and sustainable degradation over several days.
Enhanced antioxidant capability was observed in the hydrogel containing silymarin and biosynthesized zinc oxide nanoparticles.
Histopathological analysis showed improved cell growth, tissue regeneration, collagen deposition, and neovascularization in treated wounds.

AI simplified

Multifunctional wound dressings have been applied for burn injuries to avoid complications and promote tissue regeneration. In the present study, we fabricated a natural alginate-chitosan hydrogel comprising silymarin and green-synthesized zinc ‎oxide ‎nanoparticles (ZnO NPs). Then, the physicochemical attributes of ZnO NPs and loaded hydrogels were analyzed. Afterward, wound healing efficacy was evaluated in a rat model of full-thickness dermal burn wounds. The findings indicated that ZnO NPs were synthesized via reduction with phytochemicals from Elettaria cardamomum seeds extract. The microscopic images exhibited fairly spherical ZnO NPs (35-45 nm), and elemental analysis verified the relevant composition. The hydrogel, containing silymarin and biosynthesized ZnO NPs, displayed a uniform appearance, smooth surfaces, and a porous structure. Moreover, infrared spectroscopy ‎identified functional groups, confirming the successful loading without adverse interactions. The obtained hydrogel exhibited great water absorption, high porosity, sustainable degradation for several days, and enhanced antioxidant capability of the combined loaded component. In vivo studies revealed faster and superior wound healing, achieving nearly complete closure by day 21. Histopathology confirmed improved cell growth, tissue regeneration, collagen deposition, and neovascularization. It is believed that this multifunctional hydrogel-based wound dressing can be applied for effective burn wound treatment.

Full Text

Full text is available at the source.

View full text (XML) ↗View full text ↗

Enhanced healing of burn wounds by multifunctional alginate-chitosan hydrogel enclosing silymarin and zinc ‎oxide ‎nanoparticles

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week: