The facile fabrication of wound compatible anti-microbial nanoparticles encapsulated Collagenous Chitosan matrices for effective inhibition of poly-microbial infections and wound repairing in burn injury care: Exhaustive in vivo evaluations

Jul 14, 2019Journal of photochemistry and photobiology. B, Biology

Easy production of collagen-chitosan wound dressings with antimicrobial nanoparticles to prevent infections and help heal burn wounds: thorough animal testing

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Abstract

ZnO loaded collagen/chitosan nanofibrous materials demonstrated enhanced antibacterial activity against S. aureus and E. coli.

Citrus pectin stabilizes the synthesis of ZnO nanoparticles.
ZnO nanoparticles were incorporated into collagen/chitosan nanofibers using an electrospinning method.
The nanofibrous material showed suitable properties for wound healing, including favorable chemical structure and morphology.
In vitro studies indicated enhanced cell proliferation and viability over 3 days, comparable to control materials.
In vivo tests on rat models showed that the ZnO loaded collagen/chitosan nanofibers may accelerate wound healing in the initial stages.

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Treatment of burn injury is clinically challenging one, therefore several steps and noteworthy approaches have been taken to improve wound mechanisms. Citrus pectin plays a stabilizing agent to synthesis of ZnO nanoparticles (ZnO NPs). The present study is focused on ZnO loaded collagen/chitosan nanofibrous were synthesized by electrospinning method using ZnO NPs. The chemical structure, phase purity and morphological observation were investigated under spectroscopic and mircoscopic techniques and demonstrated their suitable properties as a wound healing material. In addition, that prepared nanoparticles loaded biopolymeric fibrous nanomaterial showed suitable antibacterial activity against S. aureus and E. coli bacterial pathogens and also in vitro studies was confirmed the enhanced proliferation, cell viability and biocompatibility. In vitro evaluations have been exhibited acceptable cell proliferation is observed throughout the ZnO loaded Coll/CS nanofibrous within 3 days, which was comparable to the control material. In vivo wound healing ability was monitored on the rat wound experimental model. From the in vivo observations, revealed that the loaded of ZnO NPs with Coll/CS nanofibrous can effectively quicken wound healing mechanism, expressed in the initial stage healing process. These results suggest that ZnO loaded collagen/chitosan nanofibrous is a potential candidate for wound healing applications with enhanced biological properties.

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The facile fabrication of wound compatible anti-microbial nanoparticles encapsulated Collagenous Chitosan matrices for effective inhibition of poly-microbial infections and wound repairing in burn injury care: Exhaustive in vivo evaluations

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