Enterogenic dementia: defining the gut–brain axis and the role of inflammatory bowel disease in cognitive impairment

Oct 1, 2025Inflammopharmacology

Gut-brain connection and how inflammatory bowel disease may relate to memory and thinking problems

AI simplified

Gut-Brain Axis on OpenScience ↗PubMed ↗DOI ↗

Abstract

Dementia may be linked to inflammatory bowel disease (IBD) through various mechanisms.

Chronic inflammatory and immunological diseases could contribute to the development of dementia via neuroinflammation and synaptic dysfunction.
IBD is associated with gut dysbiosis and systemic inflammation, which may play roles in the onset of dementia.
The interaction between the gut and brain, known as the gut-brain axis, is suggested to be a critical factor in the relationship between IBD and dementia.
The exact mechanisms connecting IBD to dementia remain unclear and require further investigation.

AI simplified

Dementia is a clinical syndrome due to brain neurodegeneration and associated oxidative stress and neuroinflammation. Chronic inflammatory and immunological diseases are associated with the development of dementia due to the development of neuroinflammation and synaptic dysfunction. Dementia is commonly related to inflammatory bowel disease (IBD), which may be named as an enterogenic dementia, which results from gut dysbiosis, systemic inflammation, and neuroinflammation. IBD is regarded as a potential risk factor for the development and progression of dementia, known as enterogenic dementia, through different mechanisms such as alteration of the gut-brain axis and gut dysbiosis. However, the precise mechanism linking IBD and dementia is not fully elucidated and remains elusive. In this perspective, we try to discuss the mechanisms for the development and progression of enterogenic dementia in relation to IBD and gut dysbiosis.