Epigenomics

Epigenetic aging is not closely linked to fitness in heart failure patients: a pilot study

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

DNA methylation epigenetic clocks may offer complementary insight into heart failure prognosis.

  • Standard measures like left ventricular ejection fraction do not fully reflect individual differences in heart failure status.
  • Cardiopulmonary exercise testing also has limitations in assessing prognosis in heart failure patients.
  • DNA methylation epigenetic clocks estimate biological age and epigenetic age acceleration.
  • These clocks could provide additional information related to cardiorespiratory fitness in heart failure.
  • Understanding systemic aging in heart failure may be enhanced through these epigenetic measures.

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