Differences in epigenetic age acceleration according to a diagnosis of endometriosis/adenomyosis: the Norwegian Mother, Father and Child Cohort Study

In a study of 234 women with endometriosis or adenomyosis, no meaningful differences in epigenetic age acceleration were found compared to 3,508 women without these conditions.

• The unadjusted analysis showed a modest epigenetic age deceleration in women with endometriosis/adenomyosis using the Horvath pan-tissue clock.
• This deceleration had a mean difference in the z-score of -0.15, with a 95% confidence interval from -0.28 to -0.02.
• Other established clocks indicated no notable differences in epigenetic age acceleration, with mean differences in z-scores ranging from -0.10 to 0.06.
• After adjusting for factors such as chronological age and body mass index, the significant difference in the Horvath clock was diminished, showing a mean difference of 0.00.

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