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Abstract
Over 170 distinct RNA modifications are involved in gene regulation within the epitranscriptome.
- RNA modifications, including N-methyladenosine, 5-methylcytosine, and pseudouridine, affect RNA processing, localization, stability, and translation.
- In cancer, these modifications interact with oncogenic signaling networks, impacting cell proliferation, metabolism, immune evasion, stemness, and resistance to therapy.
- Recent advancements in detection and profiling technologies have enhanced the understanding of the epitranscriptome's roles in cancer.
- A mechanistic framework links RNA modifications and their regulators to key characteristics of cancer.
- Emerging evidence suggests that epitranscriptomic regulators may interface with established cancer pathways, indicating their potential as biomarkers and therapeutic targets.
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