Full text is available at the source.
Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System
How m6A RNA Modifications May Affect Nerve Fiber Regrowth in Adult Mammals
AI simplified
Abstract
Sciatic nerve injury increases levels of N-methyladenosine-tagged transcripts associated with regeneration in adult mouse dorsal root ganglion.
- N-methyladenosine is linked to the regulation of mRNA metabolism and decay in the nervous system.
- Injury to the sciatic nerve elevates mA-tagged transcripts related to regeneration and protein translation in adult mice.
- A dynamic mA landscape is observed in adult dorsal root ganglion following nerve injury.
- Depletion of the mA methyltransferase complex component Mettl14 or the mA-binding protein Ythdf1 reduces protein translation and impairs axon regeneration.
- Knockdown of Mettl14 diminishes axon regeneration in retinal ganglion neurons following Pten deletion in the central nervous system.
AI simplified