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How m6A RNA Modifications May Affect Nerve Fiber Regrowth in Adult Mammals
Updated
Abstract
Sciatic nerve injury increases levels of N-methyladenosine-tagged transcripts associated with regeneration in adult mouse dorsal root ganglion.
- N-methyladenosine is linked to the regulation of mRNA metabolism and decay in the nervous system.
- Injury to the sciatic nerve elevates mA-tagged transcripts related to regeneration and protein translation in adult mice.
- A dynamic mA landscape is observed in adult dorsal root ganglion following nerve injury.
- Depletion of the mA methyltransferase complex component Mettl14 or the mA-binding protein Ythdf1 reduces protein translation and impairs axon regeneration.
- Knockdown of Mettl14 diminishes axon regeneration in retinal ganglion neurons following Pten deletion in the central nervous system.
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