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Selective removal of cell's protein-folding system parts influences aging, cell structure, and lifespan
Updated
Abstract
ER mass declines significantly with aging, shifting from rough sheets to tubular structures in various organisms.
- ER remodeling is a consistent feature across species, from yeast to mammals, during aging.
- As animals age, the transition of ER morphology is associated with a shift in function from protein synthesis to lipid metabolism.
- ER-phagy is activated early in adulthood to manage the increased burden of misfolded proteins, leading to turnover of rough ER.
- Impairment of ER-phagy has been linked to a reduced lifespan in yeast.
- Enhancements in lifespan are correlated with significant changes in ER morphology, even in young animals.
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