Early trial of under-the-skin esketamine for hard-to-treat depression with added ketamine therapy

Ketamine produces antidepressant effects within hours in individuals with treatment-resistant depression.

• Ketamine is associated with rapid relief of depressive symptoms.
• The treatment may enhance neuroplasticity, or the brain's ability to change and adapt.
• Psychotherapy could potentially amplify the antidepressant effects of ketamine.

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