Comparison of estimated glomerular filtration rate change with sodium‐glucose cotransporter‐2 inhibitors versus glucagon‐like peptide ‐1 receptor agonists among people with diabetes: A propensity‐score matching study

SGLT2 inhibitor use was associated with a slower decline in kidney function, with an average change in eGFR of -1.41 mL/min/1.73 m compared to -2.62 mL/min/1.73 m for GLP-1RA users.

• The analysis included 2549 individuals with diabetes after matching by propensity score.
• Participants had a median age of 52 years, with a majority being men (80.6%).
• SGLT2 inhibitors are linked to a less severe decline in kidney function compared to GLP-1RAs.
• The estimated glomerular filtration rate (eGFR) decline was less pronounced in SGLT2 inhibitor users.

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